Cutting-edge molecular profiling analyses reveal that the popular weedkiller Roundup causes serious liver damage to rats at low doses permitted by regulators, reports Claire Robinson. The findings suggest that residues of glyphosate-based herbicides in food could be linked to rises in the incidence of non-alcoholic fatty liver disease, obesity, diabetes and ‘metabolic syndrome’.
The weedkiller Roundup causes non-alcoholic fatty liver disease at very low doses permitted by regulators worldwide, a new peer-reviewed study published by a Nature journal shows.
The study is the first ever to show a causative link between consumption of Roundup at a real-world environmentally relevant dose and a serious disease.
Virtually all doctors agree that elevated insulin resistance is very bad for human health, being the root cause of type 2 diabetes and metabolic syndrome. So, if it is so bad, why do we all develop it in the first place? How can such a mal-adaptive process be so ubiquitous?
As of 2015, over 50% of the American population has diabetes or pre-diabetes. This stunning statistic means that there are more people in the United States with pre-diabetes or diabetes than without it. It’s the new normal. Why does it develop it so frequently? There must be some protective purpose to it since our bodies are not designed to fail. Humans have lived for millennia before the modern diabesity epidemic. How can insulin resistance be protective?
You can discover many things by taking a different perspective. The golden rule states “Do unto others as you would have them do unto you.” A well-known quote says, “Before you judge me, walk a mile in my shoes”. In both cases, the key to success is change perspective. Invert (turn upside down) your perspective, and see how your horizons are immensely broadened. So let’s look at the development of insulin resistance from the opposite angle. Let’s not consider why insulin resistance is bad, but rather, why it is good.
You don’t have to love dogs to appreciate the brilliance of this book on canine obesity, but it helps. It makes it easier to see why Dogs, Dog Food, and Dogma really is a riveting read. One reason is the subtitle: The Silent Epidemic Killing America’s Dogs and the New Science That Could Save Your Best Friend’s Life.
It reveals the bare bones of the raison d’etre: evidence-based solutions to the epidemic of canine obesity.
Another reason is that this book isn’t just about canine obesity. It’s also about another global epidemic: of human adipose tissue. That’s the medical profession’s euphemism for excess fat. This book looks at why obesity shortens lives, whether canine or human. And why even moderate obesity in dogs is more dangerous for them than smoking is in humans.
Starchy foods are the main sources of carbohydrates; however, there is limited information on their metabolic impact. Therefore, we assessed the association between carbohydrates from starchy foods (Carb-S) intakes and the metabolic disorders of metabolic syndrome (MetS) and hyperlipidemia. In this study, 4,154 participants from Northern China were followed up for 4.2 years. Carb-S included rice, refined wheat, tubers, and their products. Multivariable regression models were used to calculate risk ratios (RRs) for MetS and hyperlipidemia from Carb-S, total carbohydrates, and carbohydrates from other food sources (Carb-O). Receiver operating characteristic analysis was used to determine a Carb-S cut-off value. High total carbohydrate intake was associated with increased risks of MetS (RR: 2.24, 95% CI: 1.00–5.03) and hyperlipidemia (RR: 3.05, 95% CI: 1.25–7.45), compared with the first quartile. High Carb-S intake (fourth quartile) was significantly associated with MetS (RR: 1.48, 95% CI: 1.01–2.69) and hyperlipidemia (RR: 1.73, 95% CI: 1.05–3.35). No associations with Carb-O were observed. Visceral adiposity, triglyceride levels, and high-density lipoprotein cholesterol significantly contributed to the metabolic disorders. The Carb-S cut-off value was 220 g. Both high total carbohydrate and Carb-S intakes were associated with hyperlipidemia and MetS; Carb-S appears to contribute more to these disorders.
US investigative journalist Nina Teicholz calls it “a victory for science.” South African scientist Tim Noakes says it proves that one person can “change the world.” I say it’s a decisive defeat for medical, scientific and dietetic establishments in their ongoing war against the critics.
The BMJ (formerly the British Medical Journal) has announced that it will not retract the peer-reviewed investigation it published by Teicholz in September 2015. The feature documents in detail how the US Dietary Guidelines (DGAs) have ignored vast amounts of rigorous scientific evidence. This evidence is on key issues such as saturated fats and low-carbohydrate diets.
Teicholz’s article has been the target of an unprecedented retraction effort that was organized by an advocacy group that has long defended those guidelines. The BMJ stance is becoming a lesson in unintended consequences for those attempting to stifle debate on the topic. It raises fundamental questions about who was behind the retraction effort and their motivation.
Fatty liver is a duck or goose is known as Foie Gras. But humans get it too. Here it’s known as fatty liver disease or non alcoholic steatohepatitis (NASH). How do we get NASH? It all comes down to what we eat.
Foods are broken down in the stomach and small intestine for easier absorption. Proteins are broken into amino acids. Fats are broken into fatty acids. Carbohydrates, composed of chains of sugars, are broken into smaller sugars. Carbohydrates raise blood glucose where proteins and fats do not. Some carbohydrates, particularly sugars and refined grains raise blood glucose effectively, which stimulates insulin release.
Dietary protein also raises insulin levels but not blood glucose by simultaneously raises other hormones such as glucagon and incretins. Dietary fats raise both blood glucose and insulin levels minimally. Absorption of fatty acids differs markedly from both amino acids and sugars. Amino acids and sugars are delivered through the intestinal bloodstream, known as the portal circulation, to the liver for processing. The liver requires insulin signaling for proper management of these incoming nutrients.